Cellular and Molecular Immunology

Investigating immune regulation, metabolism and inflammation to undestand immunological self tolerance.

About the Lab

The Matarese Lab focuses to the molecular mechanisms regulating immune responses, with particular emphasis on the interplay between metabolism, inflammation and autoimmunity. Our research integrates immunology, molecular biology and translational medicine to identify novel therapeutic targets and biomarkers. The lab is committed to advancing scientific knowledge through interdisciplinary collaboration, rigorous methodology and international partnerships.

Research Areas

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Immune regulation and autoimmunity

Understanding how metabolic pathways influence immune cell differentiation and function.

Immunometabolism

Deciphering mechanisms underlying chronic inflammatory and autoimmune disorders.

Immunological basis of obesity

Understanding how metabolic pathways influence immune cell differentiation and function.

Hypothalamc control of body weight and immunity

Deciphering mechanisms underlying chronic inflammatory and autoimmune disorders.

Latest Publications

Explore our most recent peer-reviewed publications and scientific contributions.

The immunoregulatory role of progesterone during embryo implantation and pregnancy

Colamatteo A, Carbone F, Fusco C, Russo C, Micillo T, Carluccio D, La Rocca C, Zheng W, Longobardi S, Matarese G.
Trends Endocrinol Metab. 2026 Apr 1:S1043-2760(26)00044-5.

Physical exercise modulates T cell activity and mitigates synaptic dysfunction in multiple sclerosis through vagus nerve engagement.

Musella A, Balletta S, Russo C, Mariani F, Tartacca A, Rosa G, Vito F, Palmerio F, Fresegna D, Bruno A, Dolcetti E, Caioli S, Escarrat V, Buttari F, Carbone F, la Candia A, ...., Salvetti M, Matarese G, Mandolesi G, Procaccini C, Centonze D, Gentile A.
Brain Behav Immun. 2026 Mar 2:106523.

Immunophenotypic skewing of B cells toward IgD⁻CD27⁻IgG⁺ subtype and metabolic attenuation in colorectal cancer.

Martinis E, Tonon S, Valeri V, Colamatteo A, Ricci C, Trevisan C, Capezzali E, Pivetta M, Battista S, Mozzon M, Uzzau A, Matarese G, Cossarizza A, Frossi B, Pucillo C.
Sci Rep. 2026 Feb 28. doi: 10.1038/s41598-026-41446-x.

Effect of dynamics and timing of SARS-CoV-2 vaccination on immune response in people with multiple sclerosis during cladribine treatment

Russo C, Fusco C, Carbone F, Micillo T, La Rocca C, De Rosa G, Di Marino V, Ruggiero K, Garziano F, Perna F, Zannella C, Galdiero M, Franci G, Lanzillo R, Brescia Morra V, Bigi R, Abbadessa G, Bonavita S, Salvetti M, Moccia M, Procaccini C, Matarese G.
Clin Immunol. 2026 Feb 17;284:110683. doi: 10.1016/j.clim.2026.110683

The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.

Racioppi L, Matarese G, D'Oro U, De Pascale M, Masci AM, Fontana S, Zappacosta S.
Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10360-5.

T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down’s syndrome.

Scotese I, Gaetaniello L, Matarese G, Lecora M, Racioppi L, Pignata C.
Pediatr Res. 1998 Aug;44(2):252-8.